Cardiac risk stratification in cancer patients: A longitudinal patient–patient network analysis

Cardiovascular disease is a leading cause of death in general population and the second leading cause of mortality and morbidity in cancer survivors after recurrent malignancy in the United States. The growing awareness of cancer therapy–related cardiac dysfunction (CTRCD) has led to an emerging field of cardio-oncology; yet, there is limited knowledge on how to predict which patients will experience adverse cardiac outcomes. We aimed to perform unbiased cardiac risk stratification for cancer patients using our large-scale, institutional electronic medical records.

Authors: Yuan Hou ,Yadi Zhou ,Muzna Hussain ,G. Thomas Budd,Wai Hong Wilson Tang,James Abraham,Bo Xu,Chirag Shah,Rohit Moudgil,Zoran Popovic,Chris Watson,Leslie Cho,Mina Chung,Mohamed Kanj,Samir Kapadia,Brian Griffin,Lars Svensson,Patrick Collier ,Feixiong Cheng

Publications: PLOS Medicine, August 2, 2021

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Network medicine for disease module identification and drug repurposing with the NeDRex platform

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Network medicine links SARS-CoV-2/COVID19 infection to brain microvascular injury and neuroinflammation in dementia-like cognitive impairment