Molecular networks in Network Medicine: Development and applications

https://doi.org/10.1002/wsbm.1489

Authors: Edwin K. Silverman, Harald H. H. W. Schmidt, Eleni Anastasiadou, Lucia Altucci, Marco Angelini, Lina Badimon, Jean‐Luc Balligand ,Giuditta Benincasa, Giovambattista Capasso, Federica Conte, Antonella Di Costanzo, Lorenzo Farina, Giulia Fiscon, Laurent Gatto, Michele Gentili, Joseph Loscalzo, Cinzia Marchese Claudio Napoli, Paola Paci, Manuela Petti, John Quackenbush, Paolo Tieri, Davide Viggiano, Gemma Vilahur, Kimberly Glass, Jan Baumbach

Published: WIREs Systems Biology and Medicine

The Visual Analytics cycle applied to Network Medicine. Data from different domains (e.g., cellular, molecular, and genetic networks) are input to two different processes, Visual Data Exploration which exploits visualization paradigms (Node‐Edge, Matrix, Chords, etc.) to represent these data and classic Automated Data Analysis through different approaches (machine learning, network analysis algorithms, etc.). These two processes are interconnected, allowing an analyst to steer algorithms by interacting with the visual representation of results. The whole process generates new insights (e.g., relationships among networks) used as a feedback loop for new cycles of analysis.

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